Moreover, retained introns that are predicted not to introduce an NMD-eliciting ... to down-regulate transcripts from genes, the expression of which is either not ...
14 Nov 2019 ... The fate of an intron to be, or not to be, retained in the mature transcript ... of genes with neuron-specific functions and down-regulation of genes ...
8 Apr 2017 ... However, the “non-productive” label should not be taken to imply lack ... Intron retention is most often associated with down-regulation of gene ...
11 Apr 2018 ... IntEREst is an R package for Intron retention and exon-exon junction ... application of IntEREst is not limited to the comparison of these intron types. ... This results in a more symmetric distribution of up/down regulated intron retention signals (Fig ... Braunschweig U, Barbosa-Morais NL, Pan Q, Nachman EN, ...
16 Nov 2017 ... Intron-retaining genes have significantly longer 3′ UTR sequences, with a ... We argue therefore in zebrafish that IR is not as important ... Braunschweig U, Barbosa-Morais NL, Pan Q, Nachman EN, Alipanahi ... is accompanied by up-regulation of p27kip1 and down-regulation of CDK2, CDK4, and CDK6.
An increase in Cl− conductance produces membrane depolarization. ... Contractile responses to NE and 5-HT but not to KCl are potentiated in low-Cl− buffer. ... VSM anion channels would allow inward movement down their concentration ...
While introns do not encode protein products, they are integral to gene expression regulation. Some introns themselves encode functional RNAs through further ...
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